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Figure. 10 | Veterinary Research

Figure. 10

From: The CD2v protein of African swine fever virus inhibits macrophage migration and inflammatory cytokines expression by downregulating EGR1 expression through dampening ERK1/2 activity

Figure. 10

CD2v inhibits the expression of inflammatory cytokines in swine macrophages. Various derivatives of PAM were treated with 2 μg/mL LPS for 4 h. The expression levels of inflammatory cytokine genes were evaluated by qPCR. A Relative expression levels of gene IL-1α, IL-1β, IL6, IL8, and TNFα in PAM-GFP and PAM-CD2v (*** P < 0.001; n = 4). B Relative expression levels of gene IL-1α, IL-1β, IL6, IL8, and TNFα in EGR1-WT and EGR1-KO PAMs (** P < 0.01; *** P < 0.001; n = 4). C Relative expression levels of gene IL-1α, IL-1β, IL6, IL8, and TNFα in PAM-CD2v-EGR1 and PAM-CD2v-GFP (** P < 0.01; *** P < 0.001; n = 4).

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Veterinary Research

ISSN: 1297-9716