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Figure 2 | Veterinary Research

Figure 2

From: The CD2v protein of African swine fever virus inhibits macrophage migration and inflammatory cytokines expression by downregulating EGR1 expression through dampening ERK1/2 activity

Figure 2

Analysis of RNA-seq data. A Volcano plot showing the RNA-seq expression analysis of PAM-CD2v compared to PAM-GFP. The plots illustrate the relationship between -log10 adjusted P-value and log2foldchange. Genes exhibiting ≥ twofold absolute value fold change meeting a 0.01 adjusted P-value threshold are highlighted in red and blue. B Heatmap and dendrogram illustrating the expression of all 64 upregulated and 213 downregulated genes. Expression: z-score of FPKM in each sample. C Histogram plot for molecular function (MF), biological process (BP), and cellular compartment (CC) gene ontology terms enriched in DEGs upon CD2v overexpressing in swine macrophage. D Histogram plots show the GSEA of the top 10 biological processes that are negatively regulated by CD2v protein.

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Veterinary Research

ISSN: 1297-9716