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Figure 8 | Veterinary Research

Figure 8

From: The CD2v protein of African swine fever virus inhibits macrophage migration and inflammatory cytokines expression by downregulating EGR1 expression through dampening ERK1/2 activity

Figure 8

EGR1 binds at the promoter regions of cell locomotion-related genes. Screenshot from IGV showing DNA sequence tag densities at gene APP (A), ID2 (B), and EPHA4 (C) locus following ChIP-seq with the indicated antibodies in PAMs. The maximum coverage for each track is shown on the left. D Relative expression levels of gene APP, EPHA4, and ID2 in PAM-GFP and PAM-CD2v (** P < 0.01; *** P < 0.001; n = 3). E Relative expression levels of gene APP, EPHA4, and ID2 in EGR1-WT and EGR1-KO PAMs (*** P < 0.001; n = 3). (F) Relative expression levels of gene APP, EPHA4, and ID2 in PAM-CD2v-EGR1 and PAM-CD2v-GFP (** P < 0.01; n = 3).

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Veterinary Research

ISSN: 1297-9716