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Figure 9 | Veterinary Research

Figure 9

From: The CD2v protein of African swine fever virus inhibits macrophage migration and inflammatory cytokines expression by downregulating EGR1 expression through dampening ERK1/2 activity

Figure 9

CD2v dampens the response to the ERK1/2 pathway through EGR1. A The Venn diagram illustrates the overlapping of EGR1 (shown in blue) and H3K27ac (shown in red) binding peaks. B The Venn diagram demonstrates the overlapped genes that are co-occupied by EGR1 and H3K27ac (black), genes containing EGR1 binding peaks within 1 kb up or downstream of their TSS (red), genes containing H3K27ac binding peaks within 1 kb up or downstream of their TSS (blue), and differential expressed genes (adjust p < 0.05 and log2FoldChange < 0) in PAM-CD2v versus PAM-GFP (green). C GO term enrichment analysis of 247 overlapped genes from B.

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Veterinary Research

ISSN: 1297-9716