Figure 8

SjANX A13 is involved in the host–parasite interaction via exosomes. A Schema of the transwell system. B Transcript levels of SjANX A13 in LX-2 cells of the transwell system. C Observation of S. japonicum worm-derived exosomes through TEM. The white arrows highlight typical structure of exosomes. Scale bar = 200 nm. D Representative images of the uptake of PKH67-labeled S. japonicum worm-derived exosomes (green) by LX-2 cells (DAPI blue). The black arrows highlight representative internalization. Scale bar = 50 μm. E Schema of exosomes and LX-2 cells co-incubation. F Transcript levels of SjANX A13 in LX-2 cells after coculture with S. japonicum worm-derived exosomes after 48 h. A and E were created with Biorender.com.