Figure 13

TAK-242 and PDTC inhibited transcription of TLR-4, NF-κB p65, and IL-1β and IL-6 in infected murine intestines. A, F qPCR analysis of TLR-4 mRNA transcription level in TAK-242 (A) and PDTC (F) group of infected mice. B, G qPCR analysis of NF-κB mRNA transcription in the TAK-242 (B) and PDTC (G) group of infected mice; C–E qPCR analysis of mRNA expression levels of IL-1β (C), IL-6 (D) and TGF-β (E) in infected mice pretreated with TAK-242; H–J qPCR analysis of mRNA expression levels of IL-1β (H), IL-6 (I) and TGF-β (J) in PDTC-pretreated infected mice. Statistical differences are marked with asterisks (*) compared to its solvent group at P < 0.05.