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Figure 6 | Veterinary Research

Figure 6

From: Vidofludimus inhibits porcine reproductive and respiratory syndrome virus infection by targeting dihydroorotate dehydrogenase

Figure 6

Vidofludimus anti-PRRSV activity is mediated by DHODH. A Effect of DHODH overexpression on PRRSV replication in Marc-145 cells. B Viability of Marc-145 cells treated with the indicated concentrations of siRNAs for 48 h. C Effect of DHODH interference on PRRSV replication in Marc-145 cells. D Effect of DHODH interference on Vi anti-PRRSV activity in Marc-145 cells. E and F Image J analysis of DHODH and PRRSV N protein quantification in (D). G Effect of Vi treatment on DHODH proviral activity in Marc-145 cells. H Image J analysis of PRRSV N protein quantification in (G). I Viability of Marc-145 cells treated with the indicated concentrations of 6-AU for 48 h. J Western blot of N-protein in PRRSV-infected cells with indicated concentrations of 6-AU or DMSO.

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Veterinary Research

ISSN: 1297-9716